{"format":1,"catalogue":{"manifest":{"releaseId":"atlas-mvo-preview-2","catalogueVersion":"2","graphVersion":"2","layoutAlgorithmVersion":"voronoi-2","applicationVersion":"0.1.0","schemaVersion":1,"assets":[]},"subjects":[{"id":"pharmacology","label":"Pharmacology","order":0}],"territories":[{"id":"general","label":"General & Clinical","summary":"Principles · Safe prescribing · Clinical development","subjectId":"pharmacology","order":0},{"id":"autonomic","label":"Autonomic & Neuromuscular","summary":"Autonomic signalling · Neuromuscular transmission","subjectId":"pharmacology","order":1},{"id":"immune","label":"Autacoids, Inflammation & Immunology","summary":"Local mediators · Inflammatory disease · Immunotherapy","subjectId":"pharmacology","order":2},{"id":"cardiovascular","label":"Cardiovascular & Renal","summary":"Blood pressure · Cardiac disease · Fluid balance","subjectId":"pharmacology","order":3},{"id":"cns","label":"CNS, Pain & Anaesthesia","summary":"Mental health · Neurology · Pain & anaesthesia","subjectId":"pharmacology","order":4},{"id":"respiratory","label":"Respiratory","summary":"Airways · Cough · Respiratory therapeutics","subjectId":"pharmacology","order":5},{"id":"endocrine","label":"Endocrine, Metabolic & Reproductive","summary":"Hormones · Metabolism · Reproductive health","subjectId":"pharmacology","order":6},{"id":"gastrointestinal","label":"GI & Hepatobiliary","summary":"Acid-peptic disease · Motility · Biliary pharmacology","subjectId":"pharmacology","order":7},{"id":"blood","label":"Blood & Haemostasis","summary":"Anaemia · Thrombosis · Bleeding","subjectId":"pharmacology","order":8},{"id":"anti-infective","label":"Anti-infective","summary":"Antimicrobial therapy · Resistance","subjectId":"pharmacology","order":9},{"id":"cancer","label":"Cancer Therapeutics","summary":"Cancer treatment · Supportive pharmacology","subjectId":"pharmacology","order":10},{"id":"toxicology","label":"Toxicology & Special Topics","summary":"Poisoning · Skin & eye · Special therapeutics","subjectId":"pharmacology","order":11}],"topics":[{"id":"pharmacodynamics","label":"Pharmacodynamics","territoryId":"general","order":0,"publication":"preview","aliases":[]},{"id":"pharmacokinetics","label":"Pharmacokinetics","territoryId":"general","order":1,"publication":"preview","aliases":[]},{"id":"dosage-and-routes","label":"Dosage & routes of administration","territoryId":"general","order":2,"publication":"preview","aliases":[]},{"id":"adverse-drug-reactions","label":"Adverse drug reactions & pharmacovigilance","territoryId":"general","order":3,"publication":"preview","aliases":[]},{"id":"drug-interactions","label":"Drug interactions","territoryId":"general","order":4,"publication":"preview","aliases":[]},{"id":"pharmacogenomics","label":"Pharmacogenomics","territoryId":"general","order":5,"publication":"preview","aliases":[]},{"id":"drug-development","label":"Clinical trials & drug development","territoryId":"general","order":6,"publication":"preview","aliases":[]},{"id":"cholinergic-pharmacology","label":"Cholinergic pharmacology","territoryId":"autonomic","order":0,"publication":"preview","aliases":["Cholinergics","Anticholinergics"]},{"id":"adrenergic-pharmacology","label":"Adrenergic pharmacology","territoryId":"autonomic","order":1,"publication":"preview","aliases":["Adrenergic Agonists"]},{"id":"autonomic-blockade","label":"Autonomic blockade","territoryId":"autonomic","order":2,"publication":"preview","aliases":["Ganglionic Blockers"]},{"id":"neuromuscular-pharmacology","label":"Neuromuscular pharmacology","territoryId":"autonomic","order":3,"publication":"preview","aliases":[]},{"id":"histamine","label":"Histamine pharmacology","territoryId":"immune","order":0,"publication":"preview","aliases":[]},{"id":"serotonin","label":"Serotonin pharmacology","territoryId":"immune","order":1,"publication":"preview","aliases":[]},{"id":"eicosanoids","label":"Eicosanoid pharmacology","territoryId":"immune","order":2,"publication":"preview","aliases":[]},{"id":"anti-inflammatory-therapy","label":"Anti-inflammatory therapy & NSAIDs","territoryId":"immune","order":3,"publication":"preview","aliases":[]},{"id":"gout","label":"Gout","territoryId":"immune","order":4,"publication":"preview","aliases":[]},{"id":"rheumatoid-arthritis","label":"Rheumatoid arthritis & disease-modifying therapy","territoryId":"immune","order":5,"publication":"preview","aliases":[]},{"id":"immunosuppression","label":"Immunosuppression & transplant pharmacology","territoryId":"immune","order":6,"publication":"preview","aliases":["Immune therapies"]},{"id":"biologic-therapies","label":"Biologic therapies","territoryId":"immune","order":7,"publication":"preview","aliases":[]},{"id":"cardiovascular-foundations","label":"Cardiovascular foundations","territoryId":"cardiovascular","order":0,"publication":"preview","aliases":[]},{"id":"hypertension","label":"Hypertension & antihypertensive therapy","territoryId":"cardiovascular","order":1,"publication":"preview","aliases":["Beta Blockers","Calcium Channel Blockers","ACE Inhibitors"]},{"id":"heart-failure","label":"Heart Failure","summary":"Explore the pharmacological approach to heart failure, from therapeutic targets to the roles of different treatments.","territoryId":"cardiovascular","order":2,"publication":"preview","aliases":["Cardiac Glycosides"]},{"id":"ischaemic-heart-disease","label":"Ischaemic heart disease","territoryId":"cardiovascular","order":3,"publication":"preview","aliases":[]},{"id":"antiarrhythmics","label":"Arrhythmias","territoryId":"cardiovascular","order":4,"publication":"preview","aliases":[]},{"id":"lipid-disorders","label":"Lipid disorders & atherosclerosis","territoryId":"cardiovascular","order":5,"publication":"preview","aliases":[]},{"id":"diuretics","label":"Diuretics & fluid pharmacology","territoryId":"cardiovascular","order":6,"publication":"preview","aliases":[]},{"id":"depression","label":"Depression","territoryId":"cns","order":0,"publication":"preview","aliases":["Antidepressants"]},{"id":"psychosis","label":"Psychosis","territoryId":"cns","order":1,"publication":"preview","aliases":["Antipsychotics"]},{"id":"anxiety-and-sleep","label":"Anxiety & sleep disorders","territoryId":"cns","order":2,"publication":"preview","aliases":["Anxiolytics"]},{"id":"epilepsy","label":"Epilepsy","territoryId":"cns","order":3,"publication":"preview","aliases":["Anticonvulsants"]},{"id":"parkinsonism","label":"Parkinsonism","territoryId":"cns","order":4,"publication":"preview","aliases":[]},{"id":"dementia","label":"Dementia","territoryId":"cns","order":5,"publication":"preview","aliases":[]},{"id":"pain-and-opioids","label":"Pain & opioid pharmacology","summary":"Explore pharmacological approaches to pain management, including opioid actions, uses and important safety considerations.","territoryId":"cns","order":6,"publication":"preview","aliases":[]},{"id":"migraine","label":"Migraine","territoryId":"cns","order":7,"publication":"preview","aliases":[]},{"id":"anaesthesia","label":"General & local anaesthesia","territoryId":"cns","order":8,"publication":"preview","aliases":[]},{"id":"dependence","label":"Dependence & substance-use pharmacology","territoryId":"cns","order":9,"publication":"preview","aliases":[]},{"id":"asthma-copd","label":"Asthma & COPD","territoryId":"respiratory","order":0,"publication":"preview","aliases":["Airway medicines","Airway inflammation"]},{"id":"cough","label":"Cough","territoryId":"respiratory","order":1,"publication":"preview","aliases":[]},{"id":"respiratory-therapeutics","label":"Respiratory therapeutics","territoryId":"respiratory","order":2,"publication":"preview","aliases":[]},{"id":"diabetes","label":"Diabetes","territoryId":"endocrine","order":0,"publication":"preview","aliases":["Diabetes medicines"]},{"id":"thyroid-disorders","label":"Thyroid disorders","territoryId":"endocrine","order":1,"publication":"preview","aliases":["Thyroid medicines"]},{"id":"pituitary-adrenal","label":"Pituitary & adrenal disorders","territoryId":"endocrine","order":2,"publication":"preview","aliases":[]},{"id":"reproductive-hormones","label":"Reproductive hormone pharmacology","territoryId":"endocrine","order":3,"publication":"preview","aliases":[]},{"id":"contraception","label":"Contraception","territoryId":"endocrine","order":4,"publication":"preview","aliases":[]},{"id":"uterine-pharmacology","label":"Uterine pharmacology","territoryId":"endocrine","order":5,"publication":"preview","aliases":[]},{"id":"bone-calcium","label":"Bone & calcium disorders","territoryId":"endocrine","order":6,"publication":"preview","aliases":[]},{"id":"acid-peptic-disease","label":"Acid-peptic disease","territoryId":"gastrointestinal","order":0,"publication":"preview","aliases":[]},{"id":"nausea-vomiting","label":"Nausea, vomiting & prokinetic therapy","territoryId":"gastrointestinal","order":1,"publication":"preview","aliases":[]},{"id":"bowel-pharmacology","label":"Bowel pharmacology","territoryId":"gastrointestinal","order":2,"publication":"preview","aliases":[]},{"id":"hepatobiliary-pharmacology","label":"Hepatobiliary pharmacology","territoryId":"gastrointestinal","order":3,"publication":"preview","aliases":[]},{"id":"anaemia","label":"Anaemia therapies","territoryId":"blood","order":0,"publication":"preview","aliases":[]},{"id":"anticoagulation","label":"Anticoagulation","territoryId":"blood","order":1,"publication":"preview","aliases":[]},{"id":"antiplatelet-therapy","label":"Antiplatelet therapy","territoryId":"blood","order":2,"publication":"preview","aliases":[]},{"id":"thrombolysis","label":"Thrombolysis","territoryId":"blood","order":3,"publication":"preview","aliases":[]},{"id":"haemostasis","label":"Haemostasis & bleeding management","territoryId":"blood","order":4,"publication":"preview","aliases":[]},{"id":"antibacterial-therapy","label":"Antibacterial therapy","territoryId":"anti-infective","order":0,"publication":"preview","aliases":["Penicillins","Cephalosporins","Macrolides","Fluoroquinolones"]},{"id":"tuberculosis-leprosy","label":"Tuberculosis & leprosy","territoryId":"anti-infective","order":1,"publication":"preview","aliases":[]},{"id":"fungal-infections","label":"Fungal infections","territoryId":"anti-infective","order":2,"publication":"preview","aliases":[]},{"id":"viral-infections","label":"Viral infections","territoryId":"anti-infective","order":3,"publication":"preview","aliases":[]},{"id":"malaria","label":"Malaria","territoryId":"anti-infective","order":4,"publication":"preview","aliases":[]},{"id":"parasitic-infections","label":"Other parasitic infections","territoryId":"anti-infective","order":5,"publication":"preview","aliases":[]},{"id":"antimicrobial-resistance","label":"Antimicrobial resistance & stewardship","territoryId":"anti-infective","order":6,"publication":"preview","aliases":[]},{"id":"cytotoxic-chemotherapy","label":"Cytotoxic chemotherapy","territoryId":"cancer","order":0,"publication":"preview","aliases":["Cancer treatments"]},{"id":"targeted-cancer-therapy","label":"Targeted cancer therapy","territoryId":"cancer","order":1,"publication":"preview","aliases":[]},{"id":"hormonal-cancer-therapy","label":"Hormonal cancer therapy","territoryId":"cancer","order":2,"publication":"preview","aliases":[]},{"id":"cancer-immunotherapy","label":"Cancer immunotherapy","territoryId":"cancer","order":3,"publication":"preview","aliases":[]},{"id":"cancer-supportive-care","label":"Supportive pharmacology in cancer","territoryId":"cancer","order":4,"publication":"preview","aliases":[]},{"id":"poisoning-antidotes","label":"Poisoning & antidotes","territoryId":"toxicology","order":0,"publication":"preview","aliases":[]},{"id":"skin-pharmacology","label":"Skin pharmacology","territoryId":"toxicology","order":1,"publication":"preview","aliases":[]},{"id":"ocular-pharmacology","label":"Ocular pharmacology","territoryId":"toxicology","order":2,"publication":"preview","aliases":[]},{"id":"vitamins-supplements","label":"Vitamins & supplements","territoryId":"toxicology","order":3,"publication":"preview","aliases":[]},{"id":"vaccines-sera","label":"Vaccines & sera","territoryId":"toxicology","order":4,"publication":"preview","aliases":[]},{"id":"drugs-in-sport","label":"Drugs in sport","territoryId":"toxicology","order":5,"publication":"preview","aliases":[]},{"id":"special-topics","label":"Other special topics","territoryId":"toxicology","order":6,"publication":"preview","aliases":[]},{"id":"cholinergics","label":"Cholinergics","territoryId":"autonomic","order":2,"publication":"retired","replacementTopicId":"cholinergic-pharmacology"},{"id":"adrenergic-agonists","label":"Adrenergic Agonists","territoryId":"autonomic","order":3,"publication":"retired","replacementTopicId":"adrenergic-pharmacology"},{"id":"anticholinergics","label":"Anticholinergics","territoryId":"autonomic","order":4,"publication":"retired","replacementTopicId":"cholinergic-pharmacology"},{"id":"ganglionic-blockers","label":"Ganglionic Blockers","territoryId":"autonomic","order":5,"publication":"retired","replacementTopicId":"autonomic-blockade"},{"id":"beta-blockers","label":"Beta Blockers","territoryId":"cardiovascular","order":6,"publication":"retired","replacementTopicId":"hypertension"},{"id":"calcium-channel-blockers","label":"Calcium Channel Blockers","territoryId":"cardiovascular","order":7,"publication":"retired","replacementTopicId":"hypertension"},{"id":"ace-inhibitors","label":"ACE Inhibitors","territoryId":"cardiovascular","order":8,"publication":"retired","replacementTopicId":"hypertension"},{"id":"cardiac-glycosides","label":"Cardiac Glycosides","territoryId":"cardiovascular","order":11,"publication":"retired","replacementTopicId":"heart-failure"},{"id":"antidepressants","label":"Antidepressants","territoryId":"cns","order":12,"publication":"retired","replacementTopicId":"depression"},{"id":"antipsychotics","label":"Antipsychotics","territoryId":"cns","order":13,"publication":"retired","replacementTopicId":"psychosis"},{"id":"anxiolytics","label":"Anxiolytics","territoryId":"cns","order":14,"publication":"retired","replacementTopicId":"anxiety-and-sleep"},{"id":"anticonvulsants","label":"Anticonvulsants","territoryId":"cns","order":15,"publication":"retired","replacementTopicId":"epilepsy"},{"id":"airway-medicines","label":"Airway medicines","territoryId":"respiratory","order":16,"publication":"retired","replacementTopicId":"asthma-copd"},{"id":"airway-inflammation","label":"Airway inflammation","territoryId":"respiratory","order":17,"publication":"retired","replacementTopicId":"asthma-copd"},{"id":"diabetes-medicines","label":"Diabetes medicines","territoryId":"endocrine","order":18,"publication":"retired","replacementTopicId":"diabetes"},{"id":"thyroid-medicines","label":"Thyroid medicines","territoryId":"endocrine","order":19,"publication":"retired","replacementTopicId":"thyroid-disorders"},{"id":"penicillins","label":"Penicillins","territoryId":"anti-infective","order":20,"publication":"retired","replacementTopicId":"antibacterial-therapy"},{"id":"cephalosporins","label":"Cephalosporins","territoryId":"anti-infective","order":21,"publication":"retired","replacementTopicId":"antibacterial-therapy"},{"id":"macrolides","label":"Macrolides","territoryId":"anti-infective","order":22,"publication":"retired","replacementTopicId":"antibacterial-therapy"},{"id":"fluoroquinolones","label":"Fluoroquinolones","territoryId":"anti-infective","order":23,"publication":"retired","replacementTopicId":"antibacterial-therapy"},{"id":"cancer-treatment","label":"Cancer treatments","territoryId":"cancer","order":24,"publication":"retired","replacementTopicId":"cytotoxic-chemotherapy"},{"id":"immune-therapies","label":"Immune therapies","territoryId":"immune","order":25,"publication":"retired","replacementTopicId":"immunosuppression"}],"assets":[],"graph":{"kinds":[{"id":"mechanism","label":"Mechanism"},{"id":"drug-class","label":"Drug class"}],"relations":[{"id":"covers","label":"Covers","from":["topic"],"to":["concept"]},{"id":"related-to","label":"Related to","from":["topic","concept"],"to":["topic","concept"]}],"nodes":[{"id":"concept-beta-blockers","label":"Beta blockers","category":"concept","kindId":"drug-class"},{"id":"concept-ace-inhibitors","label":"ACE inhibitors","category":"concept","kindId":"drug-class"},{"id":"concept-calcium-channel-blockers","label":"Calcium channel blockers","category":"concept","kindId":"drug-class"},{"id":"concept-arbs","label":"Angiotensin receptor blockers","category":"concept","kindId":"drug-class"},{"id":"concept-thiazides","label":"Thiazide diuretics","category":"concept","kindId":"drug-class"},{"id":"concept-cardiac-glycosides","label":"Cardiac glycosides","category":"concept","kindId":"drug-class"},{"id":"concept-penicillins","label":"Penicillins","category":"concept","kindId":"drug-class"},{"id":"concept-cephalosporins","label":"Cephalosporins","category":"concept","kindId":"drug-class"},{"id":"concept-macrolides","label":"Macrolides","category":"concept","kindId":"drug-class"},{"id":"concept-fluoroquinolones","label":"Fluoroquinolones","category":"concept","kindId":"drug-class"},{"id":"raas-modulation","label":"Renin–angiotensin–aldosterone system modulation","category":"concept","kindId":"mechanism"},{"id":"concept-cholinergics","label":"Cholinergic agonists","category":"concept","kindId":"drug-class"},{"id":"concept-adrenergic-agonists","label":"Adrenergic agonists","category":"concept","kindId":"drug-class"},{"id":"concept-anticholinergics","label":"Antimuscarinic drugs","category":"concept","kindId":"drug-class"},{"id":"concept-ganglionic-blockers","label":"Ganglionic blockers","category":"concept","kindId":"drug-class"},{"id":"concept-antidepressants","label":"Antidepressants","category":"concept","kindId":"drug-class"},{"id":"concept-antipsychotics","label":"Antipsychotics","category":"concept","kindId":"drug-class"},{"id":"concept-anxiolytics","label":"Anxiolytics","category":"concept","kindId":"drug-class"},{"id":"concept-anticonvulsants","label":"Antiseizure medicines","category":"concept","kindId":"drug-class"}],"edges":[{"id":"hypertension-covers-beta-blockers","relationId":"covers","from":"hypertension","to":"concept-beta-blockers"},{"id":"heart-failure-covers-beta-blockers","relationId":"covers","from":"heart-failure","to":"concept-beta-blockers"},{"id":"ischaemic-heart-disease-covers-beta-blockers","relationId":"covers","from":"ischaemic-heart-disease","to":"concept-beta-blockers"},{"id":"antiarrhythmics-covers-beta-blockers","relationId":"covers","from":"antiarrhythmics","to":"concept-beta-blockers"},{"id":"hypertension-covers-ace-inhibitors","relationId":"covers","from":"hypertension","to":"concept-ace-inhibitors"},{"id":"heart-failure-covers-ace-inhibitors","relationId":"covers","from":"heart-failure","to":"concept-ace-inhibitors"},{"id":"hypertension-covers-calcium-channel-blockers","relationId":"covers","from":"hypertension","to":"concept-calcium-channel-blockers"},{"id":"ischaemic-heart-disease-covers-calcium-channel-blockers","relationId":"covers","from":"ischaemic-heart-disease","to":"concept-calcium-channel-blockers"},{"id":"antiarrhythmics-covers-calcium-channel-blockers","relationId":"covers","from":"antiarrhythmics","to":"concept-calcium-channel-blockers"},{"id":"hypertension-covers-arbs","relationId":"covers","from":"hypertension","to":"concept-arbs"},{"id":"heart-failure-covers-arbs","relationId":"covers","from":"heart-failure","to":"concept-arbs"},{"id":"hypertension-covers-thiazides","relationId":"covers","from":"hypertension","to":"concept-thiazides"},{"id":"diuretics-covers-thiazides","relationId":"covers","from":"diuretics","to":"concept-thiazides"},{"id":"heart-failure-covers-cardiac-glycosides","relationId":"covers","from":"heart-failure","to":"concept-cardiac-glycosides"},{"id":"antiarrhythmics-covers-cardiac-glycosides","relationId":"covers","from":"antiarrhythmics","to":"concept-cardiac-glycosides"},{"id":"antibacterial-therapy-covers-penicillins","relationId":"covers","from":"antibacterial-therapy","to":"concept-penicillins"},{"id":"antibacterial-therapy-covers-cephalosporins","relationId":"covers","from":"antibacterial-therapy","to":"concept-cephalosporins"},{"id":"antibacterial-therapy-covers-macrolides","relationId":"covers","from":"antibacterial-therapy","to":"concept-macrolides"},{"id":"antibacterial-therapy-covers-fluoroquinolones","relationId":"covers","from":"antibacterial-therapy","to":"concept-fluoroquinolones"},{"id":"hypertension-covers-raas","relationId":"covers","from":"hypertension","to":"raas-modulation"},{"id":"hypertension-related-heart-failure","relationId":"related-to","from":"hypertension","to":"heart-failure"},{"id":"hypertension-related-diuretics","relationId":"related-to","from":"hypertension","to":"diuretics"},{"id":"heart-failure-related-ischaemic-heart-disease","relationId":"related-to","from":"heart-failure","to":"ischaemic-heart-disease"},{"id":"anti-inflammatory-therapy-related-pain-and-opioids","relationId":"related-to","from":"anti-inflammatory-therapy","to":"pain-and-opioids"},{"id":"biologic-therapies-related-cancer-immunotherapy","relationId":"related-to","from":"biologic-therapies","to":"cancer-immunotherapy"},{"id":"immunosuppression-related-cancer-immunotherapy","relationId":"related-to","from":"immunosuppression","to":"cancer-immunotherapy"},{"id":"eicosanoids-related-asthma-copd","relationId":"related-to","from":"eicosanoids","to":"asthma-copd"},{"id":"serotonin-related-migraine","relationId":"related-to","from":"serotonin","to":"migraine"},{"id":"antiplatelet-therapy-related-ischaemic-heart-disease","relationId":"related-to","from":"antiplatelet-therapy","to":"ischaemic-heart-disease"},{"id":"cholinergic-pharmacology-covers-cholinergics","relationId":"covers","from":"cholinergic-pharmacology","to":"concept-cholinergics"},{"id":"adrenergic-pharmacology-covers-adrenergic-agonists","relationId":"covers","from":"adrenergic-pharmacology","to":"concept-adrenergic-agonists"},{"id":"cholinergic-pharmacology-covers-anticholinergics","relationId":"covers","from":"cholinergic-pharmacology","to":"concept-anticholinergics"},{"id":"autonomic-blockade-covers-ganglionic-blockers","relationId":"covers","from":"autonomic-blockade","to":"concept-ganglionic-blockers"},{"id":"depression-covers-antidepressants","relationId":"covers","from":"depression","to":"concept-antidepressants"},{"id":"psychosis-covers-antipsychotics","relationId":"covers","from":"psychosis","to":"concept-antipsychotics"},{"id":"anxiety-and-sleep-covers-anxiolytics","relationId":"covers","from":"anxiety-and-sleep","to":"concept-anxiolytics"},{"id":"epilepsy-covers-anticonvulsants","relationId":"covers","from":"epilepsy","to":"concept-anticonvulsants"}]}},"packs":[],"firstScreen":{"readings":[],"practice":[]},"extraReadings":[],"extraSources":[],"cardCounts":{},"underReview":[],"testContent":[],"topics":{},"sizes":{},"search":{"file":"assets/content/search-c14671fc17.json","bytes":26,"sha256":"c14671fc179e48f6bafa28090a0444e748eff9da76caca3a0ac03a77f5e11ce7"},"detail":{"file":"assets/content/course-detail-eb9ac1f92d.json","bytes":31,"sha256":"eb9ac1f92d0e40e81bf9d2fbb8df55fea849e870769879f50868f07e21b5b8ea"}}